13 October 2021

[Nanomedicine] – Computing at the frontiers of nanomedicine.

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The research neutron source Hein Maier-Leibnitz (FRM II) at the Technical University of Munich (TUM) is playing an important role in the investigation of mRNA nanoparticles similar to the ones used in the Covid-19 vaccines from vendors BioNTech and Moderna. Researchers at the Heinz Maier-Leibnitz Zentrum (MLZ) used the high neutron flux available in Garching to characterize various formulations for the mRNA vaccine and thus to lay the groundwork for improving the vaccine’s efficacy.

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A major goal in nanomedicine is to make nanoparticles with the capability of in vivo targeting for both imaging and delivery of therapeutic biomolecules in the human body. One strategy to obtain a high targeting yield is to functionalize the surface of nanoparticles with targeting ligands – like antibodies or aptamers – that enhance the binding of …

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